Blood-brain barrier (BBB) disruption underlies the vasogenic edema and neuronal cell death induced by acute ischemic str......

The discovery that new neurons are produced in some regions of the adult mammalianbrain is a paradigm-shift in neuroscie......

Subcortical ischemic white matter injury (SIWMI), pathological correlate of white matter hyperintensities or leukoaraios......

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Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge,a traditional Chinese med......

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Ischemic injuries will lead to necrotic tissue damage,and post-ischemia angiogenesis plays critical roles in blood flow ......

Objective: Limb remote ischemic preconditioning(LRP)represents a new strategy for stroke treatment,but its mechanism is ......

Purpose To determine how physicians management decisions are affected by the results of brain CT perfusion (CTP) imaging......

Purpose Carotid stenosis may lead to abnormal cerebral perfusion.The aim is to quantify the association between carotid ......

Purpose To determine inter-observer reliability of manual measurements on whole brain CT perfusion (CTP) imaging.Materia......

Cerebral ischemia can cause acute damage to neurons,but how the microglia are affected during ischemia is poorly underst......

Objective Hippocampus is one of the most vulnerable regions after ischemic stroke.Until now the mechanism of ischemia-re......

Background Adult cortex has long been regarded as “non-neurogenic”.Recent studies have indicated the occurrence of neu......

Cerebral ischemia-reperfusion injury plays an important role in the evolution of brain damage through mechanisms that in......

Diabetes mellitus(DM)is a group of metabolic disease with symptoms of high blood sugar levels,which may worse the stroke......

Rationale:Transplantation of culture-expanded mesenchymal stem cells (MSCs) often results in poor cellular engraftment,s......

Ischemia elicits rapid release of various amino acids including glycine, which is the co-agonist of NMDA receptor (NMDAR......

Cysteinyl cathepsins (Cats) have been implicated in the process of angiogenesis.we investigated the role of CatK in isch......

Background and purpose: Prolonged ischemia causes blood-brain barrier(BBB)damage and increases the incidence of neurovas......

Ethnopharmacological relevance:Tongxinluo (TXL),a renowned traditional Chinese medicine,consistsof several different kin......

Objective NB-3 is a member of the F3/contactin family of neural recognition molecules, which are crucial for cell morpho......

Purpose: The extracorporeal membrane oxygenation(ECMO)cannula poses a potential for obstructing flow to the lower limb,t......

Objective Water balance between cells and extracellular compartments is essential for proper functioning of the central ......

Stroke induced by middle cerebral artery occlusion (MCAO) is a common cause of adult disability leading to motor-sensory......

Stroke is a leading cause of death,and remains a major cause of disability.Up to now,few therapies,such as early t-PA ap......

Objective: NB-3 is a member of the F3/contactin family of neural recognition molecules, which are crucial for cell morph......

Objective Netrin-1 is one of the axon-guiding molecules that are critieal for neuronal development.Netrin-1 was found to......

Objective The 14-3-3 family, a group ofmultifunctional acidic proteins, exists predominantly in the brain.Up-regulation ......

Stroke is the leading cause of disability and the third cause of death in the world.Currently, underlying mechanisms of ......

Background: Life-threatening arrhythmias resulting from ischemia is important for risk stratification of patients and fo......

Progesterone has been shown to be a neuroprotective agent for ischemic damage.Progesterone reduces infarct volume and pr......

Our laboratory has previously reported that 14-3-3g could be specifically induced by ischemia in astrocyte and has a neu......

Activation of extrasynaptic NMDA receptors (exNMDARs) initiates the neuronal death.Although growing evidence suggests th......

Objective To discuss the application of temporary vascular shunting and micro vasoanastomat for salvage of the major ves......

Oxidative stress influences neuronal cell survival and homeostasis,but the mechanisms underlying the biological effects ......

Remote ischemic preconditioning may confer the cytoprotection in critical organs.We hypothesized that limb remote ischem......

Background: Despite the indication that the beneficial effects of hypobaric hypoxia preconditioning (HHP) in heatstroke ......

@@Persistent sciatic artery (PSA) is an unusual anatomical anomaly first reported in 1832 IJ and was described angiograp......

Neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, includ......

Transient global ischemia induces selective neuronal death in the CA1 area of the hippocampus and Amaurosis fugax, a phe......

Objective To explore the effect of FES on neurogenesis in rats after middle cerebral artery occlusion (MCAO).Method The ......

星形胶质细胞在疾病和损伤条件下对神经元的功能和完整性起着重要作用。目前已经明确星形胶质细胞上表达的谷氨酸转运体2 (GLT1)在......

OBJECTIVE The present study was desighed to determine the causative links and precise correlations among microglial acti......

Exopolyphosphatase (PPX) is one of the main enzymes that degrade and release orthophosphate (Pi) from the ends of polyph......

Whether astrocytes could express N-methyl-D-aspartate receptor (NMDA-R) is still controversial.We used primary culture o......

Background A model of ischcmic injury to the spinal cord was established in pigs by clamping the thoracic descending aor......